Chemotherapeutic Studies on 2-Nitrobenzofuran Derivatives

Chemotherapeutic Studies on Transmitted Mouse Leukemia*

Transmitted mouse leukemia offers a good means of investigating the therapeutic action of chemical and physical agents on leukemic cells. There are few reports on the experimental chemotherapy of leukemia in mammals other than man, except for those on the effect of radioactive substances (8, 9, 11). Therapeutic studies on fowl leukosis are not directly applicable to mammals because leukemia of ...

Chemotherapeutic studies on transplantable mouse tumors.

Transplants of tumors were made in the lower right hind leg, and treatment was begun when the tumor volume was 150-200 mm.3 For lymphosarcoma, this was 12 to 16 days; for mammary carcinoma A ? 179955, 10 to 15 days; for mammary carcinoma 5769, 10 to 15 days; and for solid Erlich ascites tumor, 6 to 8 days after inoculation. Both mammary carcinomas were spontaneous in Strain A mice obtained from...

Studies on nicotinamide derivatives.

Studies on the Alkylation of Quinolin-2(1h)-one Derivatives

Alkylation of quinolin-2(1H)-one (1) and its C(6) and C(7) substituted dervatives (OMe, OBn, and Cl) with 2-bromoacetophenone or chloroacetone under basic condition (K2CO3 in DMF) gave a mixture of N1and O2alkylated products with the former one as a major product. However, alkylation of 8-methoxy-, 8-benzyloxy-, and 8-chloroquinolin-2(1H)-ones under the same reaction conditions gave exclusively...

CHEMOTHERAPEUTIC STUDIES ON MOUSE HEPATITIS VIRUS (2) Effect of Methanol on Mouse Hepatitis Virus in vitro

Introduction Purification of mouse hepatitis virus (MHV) has not been succeeded until recently. It has been stated that mice infected with MHV produced the interferon-like substances within the host cells, and it produced remarkable disturbance of typical infectious cycles and symptoms (ALTUCCI 1959). FANTON1 (1964) reported that he could be able to purify the MHV ,partially by the use of fluor...